Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate.
Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate.
Auteurs : Julie Candiracci [Belgique] ; Valerie Migeot [Belgique] ; Yok-Hian Chionh [Singapour] ; Fanelie Bauer [Belgique] ; Thomas Brochier [Belgique] ; Brandon Russell [États-Unis] ; Kazuhiro Shiozaki [Japon, États-Unis] ; Peter Dedon [Singapour, États-Unis] ; Damien Hermand [Belgique]Source :
- Science advances [ 2375-2548 ] ; 2019.
Descripteurs français
- KwdFr :
- ARN de transfert (génétique), Complexe-1 cible mécanistique de la rapamycine (génétique), Complexe-2 cible mécanistique de la rapamycine (génétique), Différenciation cellulaire (génétique), Glycogen Synthase Kinase 3 (génétique), Mitose (génétique), Nutriments (génétique), Phosphorylation (génétique), Prolifération cellulaire (génétique), Régulation de l'expression des gènes fongiques (génétique), Schizosaccharomyces (génétique), Transduction du signal (génétique), Élongation de la traduction (génétique).
- MESH :
- génétique : ARN de transfert, Complexe-1 cible mécanistique de la rapamycine, Complexe-2 cible mécanistique de la rapamycine, Différenciation cellulaire, Glycogen Synthase Kinase 3, Mitose, Nutriments, Phosphorylation, Prolifération cellulaire, Régulation de l'expression des gènes fongiques, Schizosaccharomyces, Transduction du signal, Élongation de la traduction.
English descriptors
- KwdEn :
- Cell Differentiation (genetics), Cell Proliferation (genetics), Gene Expression Regulation, Fungal (genetics), Glycogen Synthase Kinase 3 (genetics), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 2 (genetics), Mitosis (genetics), Nutrients (genetics), Peptide Chain Elongation, Translational (genetics), Phosphorylation (genetics), RNA, Transfer (genetics), Schizosaccharomyces (genetics), Signal Transduction (genetics).
- MESH :
- chemical , genetics : Glycogen Synthase Kinase 3, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, RNA, Transfer.
- genetics : Cell Differentiation, Cell Proliferation, Gene Expression Regulation, Fungal, Mitosis, Nutrients, Peptide Chain Elongation, Translational, Phosphorylation, Schizosaccharomyces, Signal Transduction.
Abstract
Nutrient availability has a profound impact on cell fate. Upon nitrogen starvation, wild-type fission yeast cells uncouple cell growth from cell division to generate small, round-shaped cells that are competent for sexual differentiation. The TORC1 (TOR complex 1) and TORC2 complexes exert opposite controls on cell growth and cell differentiation, but little is known about how their activity is coordinated. We show that transfer RNA (tRNA) modifications by Elongator are critical for this regulation by promoting the translation of both key components of TORC2 and repressors of TORC1. We further identified the TORC2 pathway as an activator of Elongator by down-regulating a Gsk3 (glycogen synthase kinase 3)-dependent inhibitory phosphorylation of Elongator. Therefore, a feedback control is operating between TOR complex (TORC) signaling and tRNA modification by Elongator to enforce the advancement of mitosis that precedes cell differentiation.
DOI: 10.1126/sciadv.aav0184
PubMed: 31223645
PubMed Central: PMC6584457
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Bruxelles, 61, Namur 5000</wicri:regionArea><wicri:noRegion>Namur 5000</wicri:noRegion></affiliation></author><author><name sortKey="Migeot, Valerie" sort="Migeot, Valerie" uniqKey="Migeot V" first="Valerie" last="Migeot">Valerie Migeot</name><affiliation wicri:level="1"><nlm:affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000</wicri:regionArea><wicri:noRegion>Namur 5000</wicri:noRegion></affiliation></author><author><name sortKey="Chionh, Yok Hian" sort="Chionh, Yok Hian" uniqKey="Chionh Y" first="Yok-Hian" last="Chionh">Yok-Hian Chionh</name><affiliation wicri:level="1"><nlm:affiliation>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive, 117456 Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive</wicri:regionArea><wicri:noRegion>28 Medical Drive</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Fanelie" sort="Bauer, Fanelie" uniqKey="Bauer F" first="Fanelie" last="Bauer">Fanelie Bauer</name><affiliation wicri:level="1"><nlm:affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000</wicri:regionArea><wicri:noRegion>Namur 5000</wicri:noRegion></affiliation></author><author><name sortKey="Brochier, Thomas" sort="Brochier, Thomas" uniqKey="Brochier T" first="Thomas" last="Brochier">Thomas Brochier</name><affiliation wicri:level="1"><nlm:affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000</wicri:regionArea><wicri:noRegion>Namur 5000</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Brandon" sort="Russell, Brandon" uniqKey="Russell B" first="Brandon" last="Russell">Brandon Russell</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shiozaki, Kazuhiro" sort="Shiozaki, Kazuhiro" uniqKey="Shiozaki K" first="Kazuhiro" last="Shiozaki">Kazuhiro Shiozaki</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192</wicri:regionArea><wicri:noRegion>Nara 630-0192</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dedon, Peter" sort="Dedon, Peter" uniqKey="Dedon P" first="Peter" last="Dedon">Peter Dedon</name><affiliation wicri:level="1"><nlm:affiliation>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive, 117456 Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive</wicri:regionArea><wicri:noRegion>28 Medical Drive</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hermand, Damien" sort="Hermand, Damien" uniqKey="Hermand D" first="Damien" last="Hermand">Damien Hermand</name><affiliation wicri:level="1"><nlm:affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000</wicri:regionArea><wicri:noRegion>Namur 5000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Science advances</title><idno type="eISSN">2375-2548</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Differentiation (genetics)</term><term>Cell Proliferation (genetics)</term><term>Gene Expression Regulation, Fungal (genetics)</term><term>Glycogen Synthase Kinase 3 (genetics)</term><term>Mechanistic Target of Rapamycin Complex 1 (genetics)</term><term>Mechanistic Target of Rapamycin Complex 2 (genetics)</term><term>Mitosis (genetics)</term><term>Nutrients (genetics)</term><term>Peptide Chain Elongation, Translational (genetics)</term><term>Phosphorylation (genetics)</term><term>RNA, Transfer (genetics)</term><term>Schizosaccharomyces (genetics)</term><term>Signal Transduction (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN de transfert (génétique)</term><term>Complexe-1 cible mécanistique de la rapamycine (génétique)</term><term>Complexe-2 cible mécanistique de la rapamycine (génétique)</term><term>Différenciation cellulaire (génétique)</term><term>Glycogen Synthase Kinase 3 (génétique)</term><term>Mitose (génétique)</term><term>Nutriments (génétique)</term><term>Phosphorylation (génétique)</term><term>Prolifération cellulaire (génétique)</term><term>Régulation de l'expression des gènes fongiques (génétique)</term><term>Schizosaccharomyces (génétique)</term><term>Transduction du signal (génétique)</term><term>Élongation de la traduction (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycogen Synthase Kinase 3</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>Mechanistic Target of Rapamycin Complex 2</term><term>RNA, Transfer</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Differentiation</term><term>Cell Proliferation</term><term>Gene Expression Regulation, Fungal</term><term>Mitosis</term><term>Nutrients</term><term>Peptide Chain Elongation, Translational</term><term>Phosphorylation</term><term>Schizosaccharomyces</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN de transfert</term><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Complexe-2 cible mécanistique de la rapamycine</term><term>Différenciation cellulaire</term><term>Glycogen Synthase Kinase 3</term><term>Mitose</term><term>Nutriments</term><term>Phosphorylation</term><term>Prolifération cellulaire</term><term>Régulation de l'expression des gènes fongiques</term><term>Schizosaccharomyces</term><term>Transduction du signal</term><term>Élongation de la traduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nutrient availability has a profound impact on cell fate. Upon nitrogen starvation, wild-type fission yeast cells uncouple cell growth from cell division to generate small, round-shaped cells that are competent for sexual differentiation. The TORC1 (TOR complex 1) and TORC2 complexes exert opposite controls on cell growth and cell differentiation, but little is known about how their activity is coordinated. We show that transfer RNA (tRNA) modifications by Elongator are critical for this regulation by promoting the translation of both key components of TORC2 and repressors of TORC1. We further identified the TORC2 pathway as an activator of Elongator by down-regulating a Gsk3 (glycogen synthase kinase 3)-dependent inhibitory phosphorylation of Elongator. Therefore, a feedback control is operating between TOR complex (TORC) signaling and tRNA modification by Elongator to enforce the advancement of mitosis that precedes cell differentiation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31223645</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>29</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2375-2548</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>06</Month></PubDate></JournalIssue><Title>Science advances</Title><ISOAbbreviation>Sci Adv</ISOAbbreviation></Journal><ArticleTitle>Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate.</ArticleTitle><Pagination><MedlinePgn>eaav0184</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1126/sciadv.aav0184</ELocationID><Abstract><AbstractText>Nutrient availability has a profound impact on cell fate. Upon nitrogen starvation, wild-type fission yeast cells uncouple cell growth from cell division to generate small, round-shaped cells that are competent for sexual differentiation. The TORC1 (TOR complex 1) and TORC2 complexes exert opposite controls on cell growth and cell differentiation, but little is known about how their activity is coordinated. We show that transfer RNA (tRNA) modifications by Elongator are critical for this regulation by promoting the translation of both key components of TORC2 and repressors of TORC1. We further identified the TORC2 pathway as an activator of Elongator by down-regulating a Gsk3 (glycogen synthase kinase 3)-dependent inhibitory phosphorylation of Elongator. Therefore, a feedback control is operating between TOR complex (TORC) signaling and tRNA modification by Elongator to enforce the advancement of mitosis that precedes cell differentiation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Candiracci</LastName><ForeName>Julie</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-3793-7350</Identifier><AffiliationInfo><Affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Migeot</LastName><ForeName>Valerie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chionh</LastName><ForeName>Yok-Hian</ForeName><Initials>YH</Initials><Identifier Source="ORCID">0000-0002-4909-8382</Identifier><AffiliationInfo><Affiliation>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive, 117456 Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Fanelie</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-5887-4806</Identifier><AffiliationInfo><Affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brochier</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Brandon</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-7260-6189</Identifier><AffiliationInfo><Affiliation>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shiozaki</LastName><ForeName>Kazuhiro</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0002-0395-5457</Identifier><AffiliationInfo><Affiliation>Division of Biological Science, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dedon</LastName><ForeName>Peter</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0003-0011-3067</Identifier><AffiliationInfo><Affiliation>Singapore-MIT Alliance for Research and Technology Centre (SMART), Center for Life Sciences 05-06, 28 Medical Drive, 117456 Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Massachusetts Institute of Technology, 56-787B77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermand</LastName><ForeName>Damien</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0002-1029-5848</Identifier><AffiliationInfo><Affiliation>URPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 ES026856</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci 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